Key Word(s): 1. colon capsule; 2. CT-colonography; 3. incomplete; 4. optical colonoscopy; Presenting Author: TIING LEONG ANG Additional Deforolimus chemical structure Authors: RAPAT PITTAYANON, SHIAW HOOI HO, RUNGSUN RERKNIMITR, KHEAN LEE GOH, ENG KIONG TEO Corresponding Author: TIING LEONG ANG Affiliations: Changi General Hospital; Chulalongkorn Hospital; University of Malaya Objective: White light endoscopy (WLE) may miss intestinal metaplasia (IM), dysplasia and early gastric cancer. Narrow band imaging (NBI) during endoscopy improves mucosal surface contrast. The current NBI system is limited by a dark endoscopic view and is only useful for characterization

of lesions. The new EXERA III NBI system (Olympus, Tokyo, Japan) with bright illumination and high

definition resolution may increase detection rate. The study aim to determine whether there was a difference in the detection rate of focal gastric lesions between WLE and NBI using the EXERA III NBI system. Methods: Three study sites were involved (Singapore, Thailand and Malaysia). Inclusion criteria: 1) subjects aged >50 years BIBW2992 clinical trial undergoing diagnostic UGI endoscopy. Exclusion criteria: 1) active gastrointestinal bleeding; 2) coagulopathy; 3) previous partial gastrectomy. Patients were randomized to either WLE or NBI. The presence of focal gastric lesions and the morphology based on the Paris classification were recorded. Lesions were biopsied and endoscopic diagnoses were confirmed by histology. The difference in the detection rate of focal lesions was analysed. Results: From January to February 2013, 421 patients were recruited (WLE: 211; NBI: 210). NBI detected

significantly more focal gastric lesions compared Pyruvate dehydrogenase to WLE (41% vs. 26.5%, p = 0.002). NBI detected significantly more cases of IM compared to WLE (20.5% vs. 5.7%; p < 0.001). These cases of IM presented as subtle mucosal abnormalities (morphology: 0_Is: 3.6%; 0_IIa: 65.5%; 0_IIb: 25.5%; 0_IIc: 5.5%). NBI detected significantly more cases of erosions or ulcers (8.6% vs. 3.8%, p = 0.45). There was no difference in the detection rate of fundic gland polyps. As only 6 cases of gastric cancer were detected, no meaningful analysis concerning its detection rate could be performed. Conclusion: NBI was useful for the detection of subtle focal gastric lesions. NBI increased the detection rate of IM compared to WLE. Key Word(s): 1. high definition; 2. narrow band imaging; 3. intestinal; 4. metaplasia; Presenting Author: JIEFU LU Additional Authors: HAIXING JIANG Corresponding Author: HAIXING JIANG Affiliations: 1st Affiliated hospital of Guangxi medical university Objective: Explore the safety and feasibility of percutaneous endoscopic gastrostomy, and the superiority compared with traditional nasogastric tube nutrition. Evaluate the effect of percutaneous endoscopic gastrostomy clinical application.