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“Resect and discard” (RD) is a new paradigm for management of diminutive (< 6mm) polyps wherein histology is determined by real-time endoscopic imaging; GDC-0941 mw polyps are then resected and discarded rather than sent for histopathological review. The ASGE states that in order to be adopted, this approach should provide >90% agreement in assignment of post-polypectomy surveillance intervals when compared to decisions based on histopathologic

review of all polyps. 1) To compare post-polypectomy surveillance recommendations between a RD approach and standard care. 2) To determine accuracy of endoscopic prediction of polyp histology. This is a prospective, observational study conducted in a single outpatient endoscopy center over 12 months. Screening and surveillance colonoscopies were performed by four academic and two community gastroenterologists. All polyps < 6mm were endoscopically imaged and histology predictions (adenoma vs. non-adenomatous polyp) were made using high-definition white light and/or narrow-band imaging (NBI) at the discretion of the endoscopist. Confidence in histologic prediction

was assessed using a visual analog scale (VAS). Diagnostic performance and accordance of recommended surveillance intervals from endoscopic imaging were compared to histopathological review of the polyps. 606 diminutive polyps were found in 315 patients (mean age 62.4 ± 8.7 years, 49% female). Histological

Epothilone B (EPO906, Patupilone) prediction RG7204 mouse could be made in 95.7% of polyps, with high confidence on VAS in 74.3%. Surveillance interval recommendations could be made for 97.4% of patients based on predictions. The accordance for recommended surveillance intervals was 82.1% compared to histopathological review. Community and academic gastroenterologists were equally accurate in their predictions (80.2% vs. 76.3%, p=0.38) and had similar accordance in recommended surveillance intervals (83.6% vs. 81.7%, p=0.74). Overall sensitivity, specificity, and accuracy of histological predictions made with high confidence were 0.81, 0.36, and 77.1% (varying 67.9-91.4%). NBI was used in 64% of predictions and did not improve accuracy of predictions (73.9% overall). Prep quality (p=0.42) and location of polyps (p=0.69) did not influence accuracy of histological predictions. Prospective RD management of diminutive polyps was not supported by our surveillance interval accordance below the 90% threshold deemed acceptable by the ASGE. Diagnostic performance using optical imaging to predict histology was equal between community and academic endoscopists. NBI utilization at the discretion of the gastroenterologist did not improve endoscopic predictions in our study. “
“The learning curve for optical diagnosis of colorectal polyps with Narrow Band Imaging (NBI) is unknown.