Major presentations have been haematamesis, abdominal pain, malena, anaemia, anorexia and dyspepsia in 24.7%, 18.5%, 18%, 12.4%, 12.4% and 9.6% in the sample respectively. NSAID s treatment was revealed in 10.7% of patients while previous

ulcer history was found in 1.1% patients. Gastric ulcer: Duodenal ulcer was 2: 1. Sex distribution of gastric ulcer was Male: female of 3: 2 while for duodenal ulcer it was 5:1. H. pylori were found in 70% of patients using CLO test. Mean age of gastric ulcer patients was 62.5 ± 13.2 SD years. Mean age of duodenal ulcer patients was 61.9 ± 14.0 SD years. Conclusion: Prevalence of peptic ulcer disease seems to be low in this cohort of patients which may be multifactorial in causation. Comparison with large multicentre trials is needed for verification. Male sex dominance had been noted in both types of ulcers, which was higher with Ipatasertib the duodenal ulcers, which correlated with worldwide pattern. Key Word(s): 1. peptic ulcer disease; Presenting Author: SHUHUI LIANG Additional Authors: XIZHANG XIZHANG, BIAOLUO BIAOLUO, HAIFENG HAIFENG, LIPING LIPING, YANI LI, MIN CHEN, YONGZHAN NIE, XIN WANG, XUEGANG GUO, KAICHUN WU, JIE DING, DAIMING FAN Corresponding Author:

KAICHUN WU, JIE DING Affiliations: Xijing hospital of digestive diseases; The Second Affiliated Hospital, XI’AN Medical University Objective: Altered www.selleckchem.com/products/Gefitinib.html expression of forkhead box Q1 (FOXQ1) is observed in various types of human cancers. However, the clinical significance of FOXQ1 expression in gastric cancer (GC) remains largely unknown. The present study aims to explore the clinicopathological significance and prognostic value of FOXQ1 in GC. Methods: FOXQ1 messenger RNA (mRNA) and protein expression were determined by quantitative real-time reverse transcriptase-polymerase chain reaction and Western blot in 20 pairs of fresh frozen GC tissues and corresponding

noncancerous tissues. Additionally, FOXQ1 expression was analyzed by immunohistochemistry in 158 clinicopathologically characterized GC cases. The correlation of FOXQ1 expression with patients’ survival rate was assessed by Kaplan–Meier and Cox regression. Results: Our selleck chemicals llc results showed that the expression levels of FOXQ1 mRNA and protein in GC tissues were both significantly higher than those in non-cancerous tissues. Our results showed that the high expression of FOXQ1 in GC was related to tumor size (P = 0.026), histological grade (P = 0.021), lymph node involvement (P = 0.002), and tumor–node–metastasis stage (P = 0.028). Kaplan–Meier survival analysis showed that a high expression level of FOXQ1 resulted in a significantly poor prognosis of GC patients. Furthermore, Cox multivariates analysis indicated that FOXQ1 expression level was an independent prognostic factor for the overall survival rate of GC patients.