All 78 cases, including 30 negative, 30 positive and 18 suspicious liver FNA cytology smears were examined with regard to nuclear area, nuclear perimeter, largest to smallest diameter ratio of the nuclei (L/S ratio) and coefficient of variation of the nuclear area (NACC). The diagnostic value was assessed using receiver operating characteristics (ROC) curves. Cutoff points were determined by the area under the ROC curve (AUC), which provides GANT61 mw the
highest combined sensitivity and specificity.
The nuclear area and perimeter in liver FNA were more helpful than L/S ratio and NACV in discriminating between hepatocytes with regenerative atypia and WD-HCC. Cutoff points of 56.67 for nuclear area and 27.16 for perimeter were suggested to help shift the suspicious diagnoses to WD-HCC.
When faced with difficult diagnoses on liver FNA, we suggest application of computerized morphometry may be a helpful ancillary diagnostic tool in the further classification of such cases. (Acta Cytol 2009;53:77-82)”
“To investigate epidemiological factors that predicts high-risk human papillomavirus (HR-HPV) types among women with atypical squamous cells of undetermined significance (ASCUS).
Case-control study of women with ASCUS and ‘reflex’
HR-HPV DNA test results Sapanisertib mw at the Prentice Ambulatory Care (PAC) outpatient clinic, MK-2206 inhibitor Northwestern University, Chicago, USA. Univariate analysis and logistic regression were done to generate measures of association between various epidemiological
variables and positive HR-HPV.
A total of 2,539 women had liquid-based Pap smear and 126 (4.96%) were confirmed ASCUS. Of the 126 with ASCUS, 125 (99.2%) had ‘reflex’ HR-HPV results. The prevalence of HR-HPV among women with ASCUS was 43.2%. Among the 54 with a positive HR-HPV, 76.0% were women < 30 years and 24.0% were a parts per thousand yen30 years. The prevalence of HR-HPV was 61.2% among women < 30 years versus 22.4% among women a parts per thousand yen30 years (P < 0.001). The mean age and standard deviations (SD) was 26.5 (6.2 years) and 34.6 (10.2 years) for women with a positive HR-HPV and negative HR-HPV test, respectively (P < 0.001). Age category < 30 years was independently predictive of HR-HPV (adjusted odds ratio 4.6, 95% CI 2.0-10.7; P < 0.001).
Age < 30 years significantly predicts presence of HR-HPV types among women with diagnosis of ASCUS. A strategy of limiting HPV testing to older women and referral of those < 30 years for colposcopic assessment appears more effective.”
“The pulsed laser deposition (PLD) growth of aluminum (Al) metal in the presence of noble background gases is studied using a Monte Carlo model constructed on the basis of SRIM 2010 calculations.