(Ann Thorac Surg 2011;92:556-61) (C) 2011 by The Society of Thoracic Surgeons ADULT CARDIAC”
“This study aimed to determine the factors that predict anosognosia in patients with Alzheimer’s disease (AD) and to examine the effect of anosognosia on patient and caregiver perceptions of the patient’s quality of life (QoL-p), using a cross-sectional design with 164 patients and their caregivers. Instruments of measurement

included Anosognosia Questionnaire-Dementia, Geriatric Depression Scale, Quality of Life in AD (QoL-AD), Disability Assessment for Dementia, Neuropsychiatric Inventory, and the Global Deterioration https://www.selleckchem.com/products/sn-38.html Scale (GDS). A binary logistic regression analysis was performed to identify the factors that predict anosognosia, while a linear regression analysis was conducted to determine the factors associated with QoL-AD. The degree of anosognosia increased in line with GDS stage (F (2,161) = 41.3, p <

0.001). In the binary regression analysis, the variables that predicted anosognosia were more neuropsychiatric symptoms (OR = 1.11, 95% CI: 1.06-1.17, p < 0.001), deficits in ADL (OR = 0.88, 95% CI: 0.83-0.94, p < 0.001), less depression (OR = 0.66, 95% CI: 0.54-0.82, p < 0.001), and older age (OR = 1.08, 95% CI: 1.00-1.15, p = 0.027). With regards to QoL-p, the multiple linear regression selleck analysis for patients (r(2) = 0.486) showed that less depression (beta = -0.52, p < 0.001) and greater anosognosia (beta = 0.40, p < 0.001) explained 33% and 10% of the variance in QoL-AD, respectively. Greater anosognosia was associated with better perceived QoL-p, check details especially in advanced GDS stages. Anosognosia was associated with greater caregiver burden and

a greater discrepancy between patient and caregiver ratings of QoL-p.”
“Through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin. A missense variant in this gene, c.2161C > T, results in the conceptual amino acid substitution p.Arg721Trp, has an allelic frequency of 0.38% in Icelanders and associates with sick sinus syndrome with an odds ratio = 12.53 and P = 1.5 x 10(-29). We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C > T but is approximately 50% for carriers of the c.2161C > T variant.”
“A sensitive electrochemiluminescence (ECL) detection of etimicin at Tris(2,2′-bipyridyl)ruthenium(II) [Ru(bpy)(3)(2+)]-Nafion modified carbon paste electrodes was developed. The immobilized Ru(bpy)(3)(2+) shows good electrochemical and photochemical activities.