10,12 Figure 2. a. Pathology of cavernous malformation: presence of multiple clustered venous structures with thin wall and blood at various stages (hematoxylin and eosin, magnification x3). b. Higher magnification of same specimen showing recent blood clot in the left … Illustrative case histories Three relevant case histories are presented in order to illustrate some of the surgical management strategies and problems. Case history 1 A 40-year-old lady with no previous medical historywas admitted following an acute headache and loss of consciousness with decreased sensorium and mild right Inhibitors,research,lifescience,medical hemiparesis.
A computed tomography (CT) scan (Figure 3a) revealed a significant left intracerebral frontal hematoma. Following insertion of a ventriculostomy, her level of consciousness improved and she gradually recovered from all neurologic deficits. MRI confirmed a large AVM in the left fronlo-opercular region (Figure 3b), and a four- vessel conventional angiogram confirmed Inhibitors,research,lifescience,medical a 4-cm AVM nidus that was fed via the MCA, dilated branches of the anterior cerebral artery, and leniiculoslriate vessels with venous drainage mostly via a dilated basal vein of Rosenthal, thus accounting for a Spetzler-Martin grade Inhibitors,research,lifescience,medical IV (http://www.selleckchem.com/products/dorsomorphin-2hcl.html Figures 3c and 3d). The patient refused preoperative embolization, and, using a
left frontotemporal craniotomy, the AVM was resected completely using standard microsurgical techniques. The patient did well postoperatively and had no speech disturbances in spite of the location close to or within the dominant Broca’s area. An angiogram peformed 1 week postoperatively confirmed the complete resection and persistence of moderate vasospasm (Figures 3e and 3f). Figure 3. a. Axial computed tomography scan showing Inhibitors,research,lifescience,medical right frontal hemorrhage and left fronto-opercular arteriovenous malformation (AVM) (case 1). B. Magnetic resonance imaging scan done 3 weeks later showing large AVM and resolving blood clot. c. and d. Right carotid … Case history
2 A 23-year-old previously healthy student was admitted to the emergency room following a severe headache accompanied by drowsiness and left hemiparesis. Inhibitors,research,lifescience,medical A CT scan revealed a significant intraparenchymal hematoma in the right parietal region (Figure 4a). Angiography revealed a high-flow AVM with a 4.5 Oxymatrine x 5 cm nidus, a large intranidal aneurysm draining into the basal vein of Rosenthal, and arterial feeders from a large distal MCA branch and accessorily from the anterior choroidal artery (Figures 4b and 4c). After stabilization of the patient who recovered completely from his deficit, a preoperative embolization was performed (10 days after the initial hemorrhage) using a mixture of bucrylate and lipiodol, which allowed for substantial reduction of the nidus (Figures 4d, 4e, and 4f). Figure 4. a. Computed tomography (CT) scan showing right temporoparietal intraparenchymal hemorrhage in a 23-year-old patient (case 2). b. and c.