[12] In a DS angiography study of 7,782 patients, four had an Az.[6] In our opinion, the disadvantage of DS http://www.selleckchem.com/products/Romidepsin-FK228.html angiography (ie, inability to reveal the whole cerebral artery network at one time) might result in confusion between an Az and a bihemispheric ACA. In addition, subjects included in

the studies are likely to be prone to cerebrovascular disorders, resulting in the proportion of Az varying between studies. These factors may be responsible for the large variation in the aforementioned incidence of the Az. This study estimated the proportion of Az in our patient population as .39% using 3-D-TOF MRA at 3.0 T. To our knowledge, this is the largest MRA study of consecutive hospitalized patients in which Az and associated aneurysms were identified and analyzed. It is believed that the results of our study are to be near to the real incidence of Az compared with the aforementioned studies. The occurrence of a dilated single trunk in the Az may increase the risk of cerebral aneurysm formation.[1],[3-6] The incidence of Az aneurysms in patients with an Az is reported as 13-71%; furthermore, such aneurysms were commonly observed at the bifurcation of the anomalous arteries.[1],[3-6] In this study, three Az-associated aneurysms were observed in 14 patients, all of them located at the distal bifurcation of the Az. Our findings

are in line with results in the published NVP-BEZ235 clinical trial MCE公司 literature.[1],[3-6] One of the possible mechanisms contributing to this location predilection is the augmentation of hemodynamic stress related to Az bifurcation geometry; that is, the hemodynamic forces on the apex of the intracranial bifurcations generated from the central stream flow could be an important factor contributing to aneurysm formation.[13, 14] This was also supported by a study conducted by Kaspera et al in which a transcranial color-coded sonography was used to assess the blood flow velocities

in the arteries of the ACA complex in patients with an Az aneurysm.[15] However, the role of increased blood flow velocity in Az remains controversial. In the aforementioned study, the authors did not agree that increased blood flow velocity in the Az was associated with aneurysm formation.[15] However, in a previously published paper, the increased blood flow velocity was considered as an important factor resulting in the development of the aneurysm.[16] Another possible factor responsible for aneurysm formation was ectasia of the Az. Ectasia may not only be a result of fusion of both A2 segments, but a result of degenerative change in the walls of the Az. Degeneration of the Az was proved by autopsy in 1 patient;[1] the pathological change may be an important factor predisposing to aneurysm formation.