12 patients (30%) underwent a Hartmann resection. All these resections were open procedures. 8 of these patients underwent a Hartmann

resection for generalized peritonitis, while #IPI-549 randurls[1|1|,|CHEM1|]# the remaining 4 underwent the same procedure for localized peritonitis or abscesses. Colo-rectal resection was performed in 11 cases (27.5%) (4 with and 7 without stoma protection). The other patients received conservative treatment (percutaneous drainage, non-operative treatment, surgical drainage and stoma). Only two (5%) underwent laparoscopic lavage and drainage. Of the 100 patients with gastro-duodenal perforations, the most frequent surgical procedure was gastro-duodenal suture. It was performed in 91 patients (91%): 85 patients underwent open gastro-duodenal suture and 6 patients underwent laparoscopic gastro-duodenal suture. Four (4%) patients underwent gastro-duodenal resection. The remaining patients (5%)

received conservative treatment (non-operative treatment, surgical drainage). Among the 53 patients with small bowel perforations, 35 underwent open small bowel resection (79.5%) and one (4.5%) underwent laparoscopic small bowel resection. Fourteen patients were treated by stoma. Two patients were treated by open drainage Among the 38 patients with colonic non-diverticular perforation, 15 patients (66%) underwent open Hartmann resection, 1 patient (2.6%) underwent laparoscopic Hartmann resection, 9 (25%) underwent open resection MK-1775 with anastomosis and without stoma protection, and 4 underwent open resection with stoma protection (10.5%). Microbiology Intraperitoneal specimens were collected from 415 (59.1%) patients. Intraperitoneal specimens were isolated from 336 of the 615 patients with community-acquired intra-abdominal infections (54.6%). Among the remaining

87 patients with healthcare-associated intra-abdominal infections, intraperitoneal specimens were collected from 79 Reverse transcriptase patients (90.9%). The major pathogens involved in intra-abdominal infections were found to be Enterobacteriaceae. The aerobic bacteria identified in samples of peritoneal fluid are reported in Table 2. Table 2 Aerobic bacteria identified in peritoneal fluid Total 455 (100%) Aerobic gram-negative bacteria 352  Escherichia coli 226(49.7%)  (Escherichia coli resistant to third generation cephalosporins) 37 (8.1%)  Klebsiella pneuumoniae 53 (11.6%)  (Klebsiella pneumoniae resistant to third generation cephalosporins) 13 (2.9%)  Klebsiella oxytoca 3 (0.7%)  Enterobacter 10 (2.2%)  Proteus 13 (2.9%)  Pseudomonas 25 (5.5%)  Others 22 (4.8%) Aerobic gram-positive bacteria 103  Enterococcus faecalis 27 (5.9%)  Enterococcus faecium 21 (4.6%)  Staphylococcus Aureus 11 (2.4%)  Streptococcus spp. 29 (6.5%)  Others 15 (3.3%) According to CIAOW Study data, ESBL producers were the most commonly identified drug-resistant microorganism involved in IAIs.