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kg/m2) correlated positively with a sustained high quality of ECC. A physical fitness test that incorporates the upper part of the body, such as rowing ergometry, facilitates the prediction of the quality of ECC. The initial quality was not significantly different between the two CVRs, but rescuer fatigue Staurosporine order occurred earlier for 30:2 than for 15:2. Female participants tended to compress too shallowly and too rapidly. Our data on rescuer fatigue strongly supported the recommendation to relieve the provider every two minutes during ECC as well as the use of feedback Inhibitors,research,lifescience,medical devices to assure high-quality chest compressions. Competing interests The authors declare that they have no competing interests. Authors’ contributions SGR conceived and designed the study, made substantial

contribution to data acquisition, performed statistical analyses and data interpretation, Inhibitors,research,lifescience,medical drafted the manuscript. PN made substantial contributions to data analyses. SR substantially recruited participants and carried out data acquisition. AT helped to draft the manuscript. AN made substantial contribution to data acquisition regarding Inhibitors,research,lifescience,medical physical fitness parameters. MQ helped to draft the manuscript. CE drafted the manuscript and made substantial contribution to data interpretation. All authors read and approved the final manuscript. Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-227X/11/20/prepub Acknowledgements We are indebted to the Göttingen Fire Department as well as Inhibitors,research,lifescience,medical to the participating nurses and medical

doctors for their willingness to support the study. The authors would like to thank Sabine Asendorf and Dr. Ursula Hilmar Vogel, both from the Section of Sports Medicine at Georg-August University of Göttingen, Germany, for their helpful assistance with the experiments of Part I. We also thank to Ingmar Lautenschläger, Department of Anaesthesiology and Intensive Care Medicine, University of Kiel, Germany, for his support during the experiments. Thanks to Dr. Günther Hahn, PhD, and Jörg Dittmar, both Inhibitors,research,lifescience,medical from the Section of Anaesthesia Research, University Medical Centre Göttingen (UMG), Germany, for performing the MatLab™ analyses as well as to Wilfrid Fraatz, Department of Medical Engineering at UMG, for evaluating the force-depth relationship of the manikin. Funding Funding has been provided solely from departmental sources.
The magnitude Bay 11-7085 of injury-related mortality and morbidity in China was highlighted by Wang and colleagues in the Health System Reform in China Series featured in The Lancet[1]. Wang et al. reported that 10% of all deaths and 30% of all potentially productive life years lost (PPYLL) were due to injury related causes. In numeric terms, this equates to the loss of approximately 850,000 lives per annum, with two-thirds of those killed being less than 45 years of age [1]. Traffic-related injury (32.3%), drowning (13.4%), falls (9.