7, 19.3, 8.0% at the end of 5 years; 44.4, 39.4, 18.2% at the end of 10 years; 60.4, 52.7, 29.1% at the end of 15 years; 71.6, 60.3, 43.1% at the end of 20 years; and 87.1, 69.8, 46.9% at the end of 25 years, respectively. The rates were significantly different among the three HCV subgroups (P < 0.001) (Fig. 1). Especially, the rates in HCV-1b of Gln70(His70) were significantly higher than those in HCV-1b of Arg70 (P = 0.028) and HCV-2a/2b (P < 0.001), and http://www.selleckchem.com/products/GDC-0980-RG7422.html the rates in HCV-1b of Arg70 were also significantly higher than those in HCV-2a/2b (P

< 0.001). During the follow-up, 104 patients (34.4%), 97 (23.4%), and 42 (10.0%) died due to liver-related causes in HCV-1b of Gln70(His70), HCV-1b of Arg70, and HCV-2a/2b, respectively. In HCV-1b of Gln70(His70), HCV-1b of Arg70, and HCV-2a/2b, the cumulative survival rates for liver-related death were 95.2, 95.4, 97.9% at the end of 5 years; 77.7, 83.3, 93.9% at the end of 10 years; 58.4, 68.4, 81.2% at the end of 15 years; 39.3, 58.4, 69.0% at the end of 20 years; and

33.8, 47.5, 59.5% at the end of 25 years, respectively. The rates were significantly different among the three HCV subgroups (P < 0.001) (Fig. 2). Especially, the rates in HCV-1b of Gln70(His70) were significantly lower than those in HCV-1b of Arg70 (P = 0.016) and HCV-2a/2b (P < 0.001), and the rates in HCV-1b of Arg70 were also significantly lower than those in HCV-2a/2b (P < 0.001). The data for

the whole population AZD6738 mouse sample were analyzed to determine those factors that could predict hepatocarcinogenesis and survival for liver-related death. Univariate analysis identified eight parameters that significantly correlated with hepatocarcinogenesis. These included gender (male; P < 0.001), age (≥60 years; P < 0.001), total bilirubin (≥1.2 mg/dL; P < 0.001), AST (≥67 IU/L; P < 0.001), ALT (≥85 IU/L; P < 0.001), platelet count (<15.0 × 104/mm3; P < 0.001), albumin (<3.9 g/dL; P < 0.001), and lifetime cumulative alcohol intake (≥500 kg; P = 0.025). Furthermore, the rates in HCV-1b of Gln70(His70) were significantly higher than those in HCV-1b of Arg70 (P = 0.028) and HCV-2a/2b 上海皓元 (P < 0.001). These factors were entered into multivariate analysis, which then identified six parameters that significantly influenced hepatocarcinogenesis independently: gender (male; HR 1.78, P < 0.001), age (≥60 years; HR 1.68, P < 0.001), albumin (<3.9 g/dL; HR 1.94, P < 0.001), platelet count (<15.0 × 104/mm3; HR 2.89, P < 0.001), AST (≥67 IU/L; HR 1.92, P < 0.001), and HCV subgroup (HCV-1b of Gln70(His70); HR 1.94, P = 0.001) (Table 2). Univariate analysis identified seven parameters that significantly correlated with survival for liver-related death. These included gender (male; P < 0.001), age (≥60 years; P < 0.001), total bilirubin (≥1.2 mg/dL; P < 0.001), AST (≥67 IU/L; P < 0.001), ALT (≥85 IU/L; P < 0.001), platelet count (<15.0 × 104/mm3; P < 0.