All participants were right-handed (the handedness of each participant was assessed by the Edinburgh Handedness

Inventory) (Oldfield 1971). The data from three participants (three women) were find more withdrawn from the analyses due to technical artifacts associated with either discomfort during testing or low optical signal due to high hair density. This study was approved by the Ethics Committees Inhibitors,research,lifescience,medical of the Sainte-Justine and Notre-Dame Hospital Centers (University of Montreal). Informed consent was obtained in writing from all participants. Stimuli The stimuli consisted of 390 written irregular words (e.g., héros [“hero”], monsieur [“sir”]) and 390 written nonwords (e.g., huyan,tirasate). Irregular words included at least one grapheme that has more than one sound correspondence. For instance, in monsieur (“sir”), the grapheme on has many sound correspondences: [œ] as in monsieur, [õ] as in chaton (“kitten”), and [ ] as in canyon] and the grapheme os in héros has at least Inhibitors,research,lifescience,medical another sound correspondence [os] as in os (“bone”). Nonwords were legal

and pronounceable according to the spelling-to-sound correspondence rules in the French orthography. However, to avoid analogical reading, nonwords did not include any homophones and bore the least resemblance to words. Each nonword was paired with an irregular word; they were matched Inhibitors,research,lifescience,medical by length (in number of letters, graphemes, phonemes, and syllables) and syllabic structure. For instance, the irregular word laps [laps] was matched with the nonword jist [ist]. The 390 stimuli were distributed into 13 blocks (each block contained 30 irregular words and 30 Inhibitors,research,lifescience,medical nonwords)

in a counterbalanced manner in terms of lexical frequency, phonological complexity (phonemic and syllabic structure), and length (number of letters, graphemes, and syllables). The 13 blocks are reported in Table A1 in the Appendix. Word frequency ranged from 0.07 to 1093 (New et Inhibitors,research,lifescience,medical al. 2001); number of letters, from 4 to 13; and number of syllables, from 1 to 4. Experimental procedure Participants underwent one session of fNIRS recording, which took place in a dark and soundproof room. All stimuli were presented to the participants on a 20-inch computer screen using the software Presentation as black low-case (Arial, 40) on a light-gray background. Each participant was seated in a comfortable chair at approximately 130 cm from the computer screen. Participants were asked to read aloud Mannose-binding protein-associated serine protease and most accurately as possible the irregular words and nonwords. As soon as they produced the irregular word, the next one would appear on the screen. If an irregular word was unknown to the participant, the investigator would immediately pass to the next one in order to avoid the participants relying on the slower phonological pathway of reading. Thus, the number of stimuli presented varied according to the participant’s reading speed, with a presentation time limit of 1.15 sec for irregular words and 1.5 sec for nonwords.