(C) 2008 Wiley-Liss, Inc.”
“AIM: To determine the incidence and characteristics of intestinal and extra-intestinal cancers

among patients with inflammatory bowel disease in a Spanish hospital and to compare them with those of the local population.\n\nMETHODS: This was a prospective, observational, 7-year follow-up, cohort study. Cumulative incidence, incidence rates based on person-years of follow-up and relative risk were calculated for patients with inflammatory bowel disease and compared with the background population. The incidence of cancer was determined using a hospital-based data registry from Hospital Universitario de Fuenlabrada. Demographic data and details about time from diagnosis of inflammatory bowel disease to occurrence HKI-272 nmr of cancer, disease extent, inflammatory bowel disease treatment, cancer therapy and cancer evolution were also collected in BI 2536 chemical structure the inflammatory bowel disease cohort.\n\nRESULTS: Eighteen of 590 patients with inflammatory bowel disease developed cancer

[cumulative incidence = 3% (95% CI: 1.58-4.52) vs 2% (95% CI: 1.99-2.11) in the background population; RR = 1.5; 95% CI: 0.97-2.29]. The cancer incidence among inflammatory bowel disease patients was 0.53% (95% CI: 0.32-0.84) per patient-year of follow-up. Patients with inflammatory bowel disease had a significantly increased relative risk of urothelial carcinoma (RR = 5.23, 95% CI: 1.95-13.87), appendiceal mucinous cystadenoma (RR = 36.6, 95% CI: 7.92-138.4), neuroendocrine carcinoma (RR = 13.1, 95% CI: 1.82-29.7) and rectal carcinoid (RR = 8.94, 95% CI: 1.18-59.7). Colorectal

cancer cases were not found.\n\nCONCLUSION: The overall risk of cancer did not significantly increase in our inflammatory bowel disease patients. However, there was an increased risk of urinary bladder cancer and, with less statistical power, an increased risk of appendiceal mucinous cystadenoma and of neuroendocrine tumors. Colorectal cancer risk was low in our series. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.”
“With a mean global incidence of 1:14500, congenital adrenal hyperplasia (CAH) is the most common VX-689 disorder of sexual differentiation (DSD). In case of female karyotype, the prenatal surplus of androgens causes virilization of the external genitalia. This includes clitoral hypertrophy and an increasing higher confluence of the urethra and normal developed proximal vagina, creating the urogenital sinus. Internal genitalia are female.\n\nUntil recently feminizing surgery was performed within the first 18 months of life, at least concerning clitoroplasty. Though the cosmetic result of this kind of surgery is quite good, functional shortcomings like clitoral hyposensibility were often reported.