Conclusion In summary, for patients with MHI,

the CCHR and the NOC have both high sensitivities for clinically important brain injury CHIR98014 mouse although this study reports much lower sensitivities than the prior published studies. Additionally, the CCHR has higher specificity, AZD2171 clinical trial PPV and NPV for important clinical outcomes than does the NOC. We believe that use of CCHR may result in reduced imaging rates, reduced costs and this would help us to protect our patients from the side effects of radiation. Limitations This study is conducted in one center. A multicenter study having larger number of patients and more trauma patients caused by much different mechanism could have been assessed. The study focused only on the two widely accepted clinical decision rules but did not study on other decision rules or aspects. Our primary outcome measure was any traumatic neurocranial lesions on the CT scan. The third limitation of this study is absence of the second outcome measure which can be defined as findings on the CT scan that led to neurosurgical intervention. References 1. Cassidy JD, Carroll LJ, Peloso PM, Borg J, Von Holst H, Holm L, Kraus J, Coronado VG: PRMT inhibitor Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. Collaborating Centre Task Force on Mild

Traumatic Brain Injury. J Rehabil Med 2004, 43:28–60.PubMedCrossRef 2. Bazarian JJ, McClung J, Shah MN, Cheng YT,

Flesher W, Kraus J: Mild traumatic brain injury in the United States, O-methylated flavonoid 1998–2000. Brain Inj 2005,19(2):85–91.PubMedCrossRef 3. Stiell IG, Clement CM, Rowe BH, Schull MJ, Brison R, Cass D, Eisenhauer MA, McKnight RD, Bandiera G, Holroyd B, Lee JS, Dreyer J, Worthington JR, Reardon M, Greenberg G, Lesiuk H, MacPhail I, Wells GA: Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury. JAMA 2005,294(12):1511–1518.PubMedCrossRef 4. Bouida W, Marghli S, Souissi S, Ksibi H, Methammem M, Haguiga H, Khedher S, Boubaker H, Beltaief K, Grissa MH, Trimech MN, Kerkeni W, Chebili N, Halila I, Rejeb I, Boukef R, Rekik N, Bouhaja B, Letaief M, Nouira S: Prediction value of the Canadian CT head rule and the New Orleans criteria for positive head CT scan and acute neurosurgical procedures in minor head trauma: a multicenter external validation study. Ann Emerg Med 2013,61(5):521–527.PubMedCrossRef 5. Hung RH: Minor Head Injury in Infants and Children. In Tintinalli’s Emergency Medicine. 7th edition. Edited by: Tintinalli JE. New York: Mc Graw- Hill; 2011:888–892. 6. Shackford SR, Wald SL, Ross SE, Cogbill TH, Hoyt DB, Morris JA, Mucha PA, Pachter HL, Sugerman HJ, O’Malley K: The clinical utility of computed tomographic scanning and neurologic examination in the management of patients with minor head injuries. J Trauma 1992,33(3):385–394.PubMedCrossRef 7.