Free Radic Biol Med 2011,51(5):942–50.PubMedCrossRef 50. Fogarty MC, Hughes CM, Burke G, Brown JC, Trinick TR, Duly E, Bailey DM, Davison GW: Exercise-induced lipid peroxidation: Implications for deoxyribonucleic acid damage and systemic free radical generation. Environ Mol Mutagen 2011,52(1):35–42.PubMedCrossRef 51. Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P: Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care 2007,30(6):1406–11.PubMedCrossRef Vemurafenib in vitro 52. Haleagrahara N, Radhakrishnan A, Lee N, Kumar P: Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats. Eur J Pharmacol 2009,621(1–3):46–52.PubMedCrossRef

53. Gomez-Cabrera MC, Borrás C, Pallardó FV, Sastre J, Ji LL, Viña J: Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol 2005,567(Pt 1):113–20.PubMedCrossRef 54. Spanou C, Veskoukis AS, Kerasioti T, Kontou M, Angelis A, Aligiannis N, Skaltsounis AL, Kouretas D: Flavonoid glycosides isolated from unique legume plant extracts as novel inhibitors of xanthine oxidase. PLoS One 2012,7(3):e32214.PubMedCrossRef

55. GSK461364 Tirkey N, Pilkhwal S, Kuhad A, Chopra K: Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol 2005, 5:2.PubMedCrossRef

Competing interests The results of the present study do not constitute endorsement of any products by the authors or by ACMS or other organizations. The authors declare that we do not have any conflicts of interest and that the source of funding is independent of the objectives and results found in this study. Authors’ contributions The authors David de Oliveira and Grace Dourado participated in the collection of data, biochemical Blebbistatin ic50 evaluation and statistical analysis. The interpretation of data and writing of the text were accomplished by all authors, including Thais Cesar, who was the mentor of this work. All authors have seen and approved the final version of this paper.”
“Background Creatine supplementation has been recognized as one of the most Amylase efficient dietary supplements capable of increasing muscle strength and lean mass [1], as well as high-intensity exercise performance [2]. However, the indiscriminate use of this supplement has raised concerns regarding its safety, especially in relation to kidney function [3]. Despite the increasing number of publications showing that creatine supplementation may not affect kidney function in humans [4–10], it has been recommended that the chronic effects of creatine supplementation should be better examined in some specific populations [3]. In this regard, there is an empirical claim that creatine supplementation might pose a risk at those consuming protein in excess.