In addition, significant serum hemagglutination inhibition (HI) and virus neutralizing (VN) antibody titers were obtained with an antigen dose as low as 5 mu g. These results demonstrate that plant-produced HA protein is antigenic and can induce immune responses in mice that correlate with protection. (c) 2008 Elsevier Ltd. All rights

reserved.”
“Objectives: This study aimed to describe the mode of refeeding, frequency of intolerance, and related factors in mild acute pancreatitis (AP).\n\nMethods: We included all cases of mild AP between January 2007 and December 2009 in an observational, descriptive, and retrospective study. We analyzed demographic and etiological data, admission variables, treatment, refeedingmode, intolerance frequency, and MLN4924 treatment. Intolerancerelated variables were determined using a Cox regression.\n\nResults: Two-hundred thirty-two patients were included (median age, 74.3 years, bedside index for severity in AP score, 1). Oral diet was reintroduced at 3 days (range, 0Y11 days) in 90.9% of cases with a liquid diet. Intolerance to refeeding appeared in 28 patients (12.1%) at a median time of 1 day (range, 0Y14 days). Oral diet was reduced

or suspended in 71.4%; analgesic and antiemetic drugs were required in 64% and 35.7% of patients, respectively. The variables independently associated CH5183284 with intolerance to refeeding were choledocholithiasis (hazard ratio [HR], 12.35; 95% confidence interval [CI], 2.98Y51.19; P = 0.001), fasting time (HR, 1.33; 95% CI, 1.09Y1.63; P = 0.005), refeeding with complete diet (HR, 4.93; 95% CI, 1.66Y14.66; P = 0.04), length of symptoms before admission (HR, 1.004; 95% CI, 1.001Y1.006; P = 0.012), and metamizole dose (HR, 1.11; 95% CI, 1.02Y1.21; P = 0.014).\n\nConclusions: Intolerance to refeeding is an infrequent event. We have identified several factors independently associated with intolerance.”
“The study aimed to assess the clinical utility in identifying CIN2 or worse (CIN2+), of the Pretect HPV-Proofer test

for E6/E7 mRNA detection in Hybrid Capture 2 (HC2)-positive patients, who underwent colposcopy. In particular, the study analyzed GSK1904529A the mRNA test performance as the third test in a subgroup of HC2+ patients with less severe than high-grade squamous intraepithelial lesions (HSIL-). We analyzed 464 cervico-vaginal samples by liquid-based cytology (LBC) and PreTect HPV-Proofer. Moreover 231 patients also had a biopsy at baseline and 75, with HSIL-, were followed up within 2 years by LBC, colposcopy, and histology when indicated. The highest sensitivity for CIN2+ belonged to the mRNA compared to LBC, at the HSIL+ threshold (72% vs. 58%), whereas the LBC showed the highest specificity and positive predictive value (PPV) (99 and 93% vs. 73 and 39%, respectively). Focusing on the 408 HSIL- patients, the mRNA positivity was significantly more associated with CIN2+ than CIN2- lesions (p < 0.0001).