Scarce data is available on the association between CYP1A1 polymorphism and increased susceptibility to thyroid cancer. Recently Bufalo et al. in an extensive study investigating CYP1A1 role in thyroid tumor igenesis and www.selleckchem.com/products/CP-690550.html its connection with GSTM1, GSTT1, GSTP1, GSTO1, and codon 72 of p53 genotypes, demonstrated an inverse association between germline CYP1A1 inheritance and smoking with the risk of thyroid nodules and papil lary carcinomas. The reasons for these divergent results are not clear but are likely racial differences because the frequencies of CYP1A1, GSTT1, GSTM1, GSTP1 and NQO1 in our con trols were different from those found in other studies. For instance certain SNPs like CYP1A1 A4889G and GSTP1 A1578G were not in Hardy Weinberg equilibrium in the control samples which is contradicting comparing to other population based data.

In order to question the specificity of the assay and to rule out the possibility of uncompleted digestion due to inactivation of enzymes or inhibitors in digestion mixture, we repeated the assays multiple and over period of time. Consistent Inhibitors,Modulators,Libraries results were obtained demonstrating this to be the Inhibitors,Modulators,Libraries true feature in our population. Consideration must also be given to potential limitation of the present study and that is the nature of the control subjects enrolled Inhibitors,Modulators,Libraries which weakens the study to be claimed purely case control. Although controls were matched with respect to age but there was gender differences, with preponderance of male blood donors.

While this initial documentation of allelic frequencies in the Arabs may be biased because of the nature of subjects enrolled, previous reports have indicated only minimal influence of age and gender on the distribution of these polymorphisms in a given population. Additionally, in our study PTC patient samples from par affin embedded tissues were readily available Inhibitors,Modulators,Libraries from the archives of the Pathology Department at King Faisal Spe cialist Hospital and Research Centre. Similarly control group was randomly selected from DNA available from peripheral blood samples at institutional Tissue Biorepository Bank at KFSHRC. It would have been ideal to analyze samples from uniform source but it was not possible in our case since archival samples were used. Since genetic aberrations, that could be present in the tumor but possibly not in the normal tissue could con found analyses but to the best of our knowledge there are no such reports suggesting somatic mutations in studied genes in thyroid cases.

Obviously, further study with a larger sample size is needed to confirm these findings and to examine the interaction between genotypes. However, this study does provide preliminary case control data on several poly morphisms in genes of the Inhibitors,Modulators,Libraries xenobiotic pathways http://www.selleckchem.com/products/kpt-330.html and risk to develop thyroid cancer.