Frequency, four properties, five flavors, and meridian were analyzed. Visualized syndrome-symptom-formula-herb system interactions had been built by bioinformatic evaluation. An overall total of 202 treatments were included, and 218 forms of TCM were involved. There were 56 herbs using the use frequency of more than 10, involving 78 syndromes and 162 symptoms. TCM remedies within the treatment of effort angina pectoris mainly included natural herbs with impacts in stimulating blood circulauyang Huanwu Decoction and Zhigancao Decoction, and their core herbs included Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix, Chuanxiong Rhizoma, Ginseng Radix et Rhizoma, Trichosanthis Fructus, Allium Macrostemonis Bulbus, Notoginseng Radix et Rhizoma, Persicae Semen, Carthami Flos, Atractylodis Macrocephalae Rhizoma, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Poria, Pinelliae Rhizoma Praeparatum. Drug properties and syndrome-symptom-formula-herb sites of TCM in the treatment of effort angina pectoris can recognize data visualization, objectively reflect the clinical problem differentiation and rule of medication, and supply guide for clinical analysis and treatment.The combo index(CI) strategy was used to judge the combination inhibition process of epicatechin gallate(ECG) and other tea polyphenols [epigallocatechin gallate(EGCG) and gallocatechin gallate(GCG)] on α-glucosidase. Herein, making use of ECG as analysis object, the surface plasmon resonance(SPR) evaluation were used to review the binding affinities and kinetic variables of three beverage polyphenols components on α-glucosidase, correspondingly. The concentration-time bend mathematical model of the drug A-674563 cell line when you look at the Cell death and immune response unstirred liquid layer(the adjacent region of α-glucosidase) established formerly by our group ended up being made use of to evaluate the concentration-time curves of this beverage polyphenols within the α-glucosidase vicinity. The prediction model of drug-α-glucosidase binding kinetics set up by our team ended up being used to evaluate the powerful means of drug-α-glucosidase binding kinetics various oral management procedures of ECG. Making use of acarbose as a reference, the accuracy of this model forecast had been evaluated based on the difference between the prediction outcomes together with actual medical performance. Utilising the mathematical style of paired NLR immune receptors drug-α-glucosidase relationship, the drug-α-glucosidase binding kinetic characteristic curves of ECG in various management processes had been obtained, which ultimately proved that the synergistic aftereffect of multi-component combination of old-fashioned Chinese medication therefore the clinical attributes of repeat administration had been medical and reasonable.The present research is designed to establish a way for determination of salidroside in plasma and areas of mice, and also to learn the pharmacokinetics and distribution qualities of salidroside in mice. After intragastrically administered of salidroside at amounts of 12.30, 36.90 and 73.80 mg·kg~(-1) to mice, plasma and structure samples had been collected, and also the focus of salidroside in each sample ended up being measured by UPLC-MS/MS to analyze plasma drug variables and tissue circulation of salidroside. Salidroside showed an excellent linear commitment within the plasma and areas of mice into the focus range of 43.40-5 556 ng·mL~(-1). The intraday and interday precision are lower than 15%, additionally the reliability is between 79.50% and 98.20%. The tissue distribution study found that salidroside had greater plasma focus, additionally the plasma concentration reached the utmost at 0.5 h. After 6 h, no salidroside ended up being recognized when you look at the plasma, showing that salidroside has great solubility and absorption quickly, approval can be quickly. In areas, the concentration of liver and kidney areas is greater, suggesting that salidroside liver and kidney would be the main metabolic and excretory body organs. The founded method is not difficult to use and has good precision. Its suitable for salidroside in mice. Pharmacokinetics and tissue distribution studies supply a reference when it comes to process of activity and medication development of salidroside.In this paper, the possible molecular process of Forsythia suspensa for the anti-tumor result had been investigated through the community pharmacology and molecular docking. The primary aspects of F. suspensa had been obtained by literary works mining and TCMSP database. Cancer-related genes had been gathered with usage of GAD and OMIM databases. The relationship community of Compounds-Targets-Pathways ended up being built through Cytoscpe software. The objectives had been reviewed by GO and KEGG indicates in DAVID database, and also the KEGG sign pathways had been visualized. Component-Target system evaluation outcomes had been verified by PyRx molecular docking. The outcome showed that an overall total of 26 primary aspects of F. suspensa may work on key goals such as for example AKT1, IL6, ESR1, EGFR, EGF and CCND1, and were associated with 20 signal paths. Molecular docking analysis revealed that hydrogen bonding, hydrophobic action and Pi-cation bonding maybe the primary types of discussion. In this research, we disclosed the anti-tumor effectation of F. suspensa through the network of Compounds-Targets-Pathways and molecular docking verification, supplying research and assistance for methodically elucidating the anti-tumor molecular process of the primary aspects of F. suspensa.To explore the system of Scutellaria barbata-Hedyotis diffusa against cancer of the breast according to community pharmacological techniques.