\n\nThe general prevalence of pain after surgery has not changed significantly over several decades despite the widespread introduction of new pain relieving technologies. The majority

of postoperative pain studies use quantitative methods which offer little understanding of the underlying GKT137831 order processes of care. Understanding can be illuminated by using an explanatory mixed method research design.\n\nDiscursive paper.\n\nThis paper focuses on the methodological considerations when using a mixed method design. Two previously published mixed methods studies illustrate how findings can inform practice. In the first, 85 women undergoing surgery completed questionnaires to measure pain, anxiety and depression. Telephone interviews explored their pain experiences. The second study considered frequency

and patterns of anxiety in the immediate pre and postoperative period. Semi-structured telephone interviews, identified contributing events/situations amenable to nursing intervention.\n\nReasons for growing popularity, criticisms, paradigmatic considerations and epistemological roots of pragmatism are explored. The two explanatory mixed method studies provide examples of these studies and how ‘inferences’ from quantitative and qualitative data can inform practice.\n\nThis paper connects quantitative and qualitative data, drawing on two research Duvelisib studies, to give greater understanding to the management of pain. Knowledge of the processes responsible for inadequate pain management can be illuminated by using explanatory mixed methods research designs.\n\nNursing requires knowledge which reflects the complexity of human health. The explanatory mixed method study can elucidate

the problem under scrutiny, e.g. prevalence of pain or anxiety. The qualitative phase can generates an understanding of contributing factors and insights for care delivery. The implicit desire to change and influence practice makes it relevant for those closely aligned to practice.”
“The aqueous extract of olive LY2835219 nmr leaves was tested for their antimicrobial activity. This extract remarkably inhibited the growth of all tested Gram-positive and Gram-negative bacteria except for Bacillus cereus CCM 99, Enterobacter aerogenes ATCC 13048 and Enterobacter cloacae ATCC 13047. The chemical constitutions of this extract were analyzed by GC/MS. GC/MS analysis of the extract resulted in the identification of fifteen constituents, representing 99.68% of the extracts; cyclotrisiloxane hexamethyl (36.98%), cyclotetrasiloxane octamethyl (15.18%) and cyclopentasiloxane decamethyl (14.59%) being the main components. To the best of our knowledge this is the first study on the olive leaves extract from West Anatolia, Turkey.