The magnitude of this risk has yet to be determined Whether IBDp

The magnitude of this risk has yet to be determined. Whether IBDpatients have an increased risk of arterial thromboembolism and cardiovascular mortality is controversial. Methods: We searched MEDLINE, Cochrane Library, and EMBASE and international conference abstracts and included all controlled observational studies that evaluated the incidence of venous and/or arterial thromboembolic events (TE) and cardiovascular mortality in adult IBD. Results: 33 studies enrolled 158 349 IBD patients and 5 774 898 controls as well

as 3 253 639 hospitalizations of IBD patients and 936 411 223 hospitalizations of controls reporting Roxadustat supplier the risk of arterial and/or venous TE (n = 18) or CV mortality Selleckchem BMS-907351 (n = 15) in IBD patients were included. The overall risk of TE was increased in IBD patients compared to the general population (RR, 1.60; 95% CI, 1.44–1.77), with no increased risk of

arterial TE (RR, 1.15; 95% CI, 0.91–1.45) and an increased risk of venous TE (RR, 1.96; 95% CI, 1.67–2.30). There were no differences between Crohn’s Disease and Ulcerative colitis. There was an increased risk of deep venous thrombosis (RR, 2.42; 95% CI, 1.78–3.30) and pulmonary embolism (RR, 2.53; 95% CI, 1.95–3.28). There was an increased risk of ischemic heart disease (RR 1.35; 95% CI 1.19–1.52). CV mortality in IBD patients was not increased compared to the general population (SMR, 1.03; 95% CI, 0.93–1.14). Conclusion: The risk of incident TE is increased VAV2 by 60% in patients with IBD compared to the general population. This increase is mainly due to an increased risk of venous TE events. There is no increased risk of overall arterial thromboembolism

and cardiovascular mortality in IBD patients, but an increased risk of both ischemic heart disease and mesenteric ischemia. Key Word(s): 1. IBD; 2. cardiovascular; 3. Thromboembolic; 4. meta-analysis; Presenting Author: P RUTGEERTS Additional Authors: B FEAGAN, C MARANO, R STRAUSS, J JOHANNS, H ZHANG, C GUZZO, JF COLOMBEL, W REINISCH, PR GIBSON, J COLLINS, G JARNEROT, WJ SANDBORN Corresponding Author: P RUTGEERTS Affiliations: University Hospital Gasthuisberg; Robarts Research Institute; Janssen Research & Development, LLC.; Janssen Services, LLC.; Hopital Claude Huriez; 5. Universitätsklinik für Innere Medizin IV; Alfred Hospital; Oregon Health Sciences; Orebro University Hospital; University of California San Diego Objective: To evaluate safety and efficacy of SC golimumab (GLM) induction in patients with moderately to severely active UC despite current adequate treatment or who had previously failed to respond to or tolerate treatment with 6-MP, AZA, corticosteroids and/or 5-ASAs or were corticosteroid dependent and were naïve to anti-TNF. Methods: PURSUIT SC had an adaptive design with Ph2 dose ranging followed by a confirmatory Ph3 component.

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