Those AHSC with hepatomegaly, splenomegaly, abnormal aminotransferase, abnormal bilirubin and/or abnormal hepatobiliary sonography were subjected to further tests (like liver function test, autoimmune hepatitis profile, glucose tolerance test, fasting find more insulin level, lipid profile, ferritin, ceruloplasmin, thyroid profile, creatine kinase, IgM antiHAV,

IgM antiHEV vitamin B12, homocysteine). Results: Among 3624 AHSC mean age=10.1±3.8 years , median age=10 years, maximum age group= 8-13 years, range=2.5-21years, girls=1395(38.4%), overweight=286(7.9%), obese=68(1.9%), hypertension=218(6%), type-2 Diabetes=1(0.02%), type-1 diabetes=2(0.05%), dyslipidemia=45(1.2%), hepatomegaly

was seen in 63(1.7%), splenomegaly=5(0.13%), abnormal aminotransferase=96(2.6%), abnormal bilirubin=17(0.46%), HBsAg positivity=1(0.02%), antiHCV positivity=0(0%) and abnormal hepatobiliary sonography=94(2.5%). Total 133(3.6%) AHSC had liver disease. Etiological spectrum was as follows: A) asymptomatic acute hepatitis in 10(0.2%) Hepatitis A=7(0.19%), Hepatitis E=2(0.05%), undetermined=1(0.02%); selleck chemicals llc B) asymptomatic chronic liver diseases in 126(3.4%) Non-alcoholic fatty liver disease[NAFLD]=123(3.3%), hepatitis B=1(0.02%)[immunotolerant phase], unexplained transaminesemia=2(0.05%).Among NAFLD(n=123), there were 3 categories: NAFLD with normal transaminase=52(42.2%),

NAFLD with elevated transaminase=24(19.5%), elevated transaminase with metabolic syndrome and/or insulin resistance(probable NAFLD)=47(38.2%). Other diseases were identified: Gilbert’s syndrome=3(0.08%), vitamin B12 deficiency=12(0.33%), extrahepatic portal venous obstruction=1(0.02%), gall stones=11(0.3%), thalassemia trait as cause for hyperbilirubinemia=4(0.11%). Conclusion: The most 上海皓元医药股份有限公司 common liver disease in AHSC is NAFLD. Viral, autoimmune or other metabolic diseases are very uncommon. Key Word(s): 1. pediatric; 2. liver disease; 3. NAFLD; Presenting Author: NIKHIL PATEL Additional Authors: DEEPAK AMARAPURKAR, SANJAY PATEL, CHETAN LAKHANI, JAYESH BHATT, RITESH PRAJAPATI, PAYAL PATEL, SULABH SOLANKI, JIGNESH SHAH Corresponding Author: NIKHIL PATEL Affiliations: nil Objective: Recently, in India, there is increasing pediatric obesity due to changing life-style and decreasing viral hepatitis due to improved hygiene and vaccination. Non-alcoholic fatty liver disease(NAFLD) is increasing in pediatric practice. Early recognition and treatment can prevent bad liver outcome in adult-hood. As there is paucity of data, this study was planned to know prevalence of obesity and NAFLD in pediatric population. Methods: This prospective study was done in 17 schools of Anand in 2012.