TUG testing was not useful for identifying patients with falls in the past week (AUC 0.47) but performed better for more distant falls in the past month, 6 months, or year. As noted in Table ​Table3,3, there were several cutoffs with negative likelihood ratios of approximately 0.30, indicating a small decrease in the likelihood of falls in the setting of a negative test. For TUG these included values ranging from 12-15 seconds depending on the time period studied. Table 2 Diagnostic performance

of testing modalities #Vandetanib cancer keyword# for predicting falls using area under the receiver-operator-characteristic curve analysis* Table 3 Test performance for predicting falls of balance testing modalities at optimal cutoff values Given reports of underreporting rates of past falls of up to 20% [23], we sought to determine what effect underreporting might have. For the TUG test,

we assumed that the highest 5 values of TUG among patients reporting no Inhibitors,research,lifescience,medical falls in the past year actually represented an unreported fall based on past reports of an association between TUG and Romidepsin side effects falling [20]. When conducting the univariate analysis for 1 year falls under this assumption, the AUC for TUG increased from 0.64 to 0.79 with 81% sensitivity and 61% specificity at a cutoff of Inhibitors,research,lifescience,medical 12 seconds. Discussion In this study of older adults being discharged from the ED, we found that over 40% reported falling within the past year. This high percentage was reported in a cohort in which no patient presented with a fall-related complaint, and is consistent with rates reported

in other studies of community-dwelling Inhibitors,research,lifescience,medical elders [21]. It demonstrates the importance of continued efforts to find effective and usable falls risk-stratification tools for older ED patients. Previous Inhibitors,research,lifescience,medical studies have largely concentrated on patient questionnaires and comprehensive geriatric assessment instruments [12,13,24,25]. Many have used additional staff with geriatrics expertise, a resource not available in most EDs [24,25]. These attempts have met with varying degrees of success. Those utilizing only ED personnel have generally been unsuccessful, likely due to failure of ED staff to follow the protocol suggestions [12,13]. As a result, future efforts should concentrate on finding modalities acceptable to and adaptable by most EDs. These would ideally be rapidly and easily implemented. For example, the TUG test requires no additional equipment and can be performed by any trained ED personnel. The balance Anacetrapib plate requires a modest initial investment, but could be adopted in EDs if purchased by them. The plate is mobile and can be kept on a small cart. It does not require recalibration with moving. The time to complete both tests in our study, although not specifically measured, was approximately 2-3 minutes. Our goal was perform a pilot study analyzing the relationships between several potential falls risk-assessment modalities in the ED setting.