[65] 1 60 Right Selleckchem SCH727965 femoral diaphysis (Taken after initial, right fracture) Minor lateral cortical thickening on left femur Yes Mild pain in right thigh before right fracture, none before left fracture Yes (GIO) ALN 8 Pred   Left femoral diaphysis (2 years later) Giusti et al. [50] 8 60 Right subtrochanteric femur   Yes Pain in right hip No

ALN 4 Ca, D, pred, inhaled GCs, esomeprazole, repaglinide, metformine, azathioprine, rosuvastatin No (6) Left subtrochanteric Selleck Saracatinib femur (9 months later) 36 Femoral shaft   No   Yes ALN 8 D, pred, simvastatine, cyclosporine, amlopidine, atenolol, lisinopril Yes 64 Left and right subtrochanteric femur (1 complete, 1 insufficiency ABT-263 molecular weight fracture)   Yes Pain in right thigh No ALN 2.5 Ca, D, pred, omeprazole, azathioprine, losartan, triamteren, HCT No (18) 62 Right and left femoral shaftb   Yes Pain in right thigh and hip Yes Oral

pamidronate 4 Ca, D, Yes 58 Femoral shaft   No Pain in left thigh Yes Intravenous pamidronate 3 Ca, D No (12) 58 Subtrochanteric femur   No Pain in left hip No RIS 5.5 Ca, D, pred, inhaled GCs, omeprazole, pravastatine, ibuprofen No (12) 72 Left subtrochanteric femur   Yes Pain in left thigh and hip Yes (GIO) Oral pamidronate followed by ALN 7 + 5 Ca, D, inhaled GCs, esomeprazole, simvastatine, captopril, irbesartan, clopidogrel Yes (12) Right subtrochanteric femur (insufficiency fracture 1 year later) 75 Femoral shaft (insufficiency fracture)     Severe pain

in left thigh and hip Yes RIS 6 Ca, D, esomeprazole, etoricoxib   Femoral shaft (insufficiency fracture 1 year later) Pain in hip ALN alendronate, BP bisphosphonate, Ca calcium, D vitamin D, FS femoral shaft, GCs glucocorticoids, GIO glucocorticoid-induced osteoporosis, HCT hydrochlorothiazide, PF proximal femur, RIS risedronate, ST subtrochanteric, Pred prednisone aMale patient bFirst fracture prior to GBA3 BP treatment; contralateral fracture following 4 years’ BP treatment; refracture of contralateral femoral shaft 4 years after second fracture cPatient was prescribed alendronate in 1996 and took it for 6 years. Fracture occurred 1 year after discontinuation and had not completely healed when reported in 2006 dPatient began teriparatide immediately after fracture In addition to case reports, several case reviews have been published, which are summarized in Table 2.