Conclusion: VEGF-C and Smad4 may play vital role in lymph Sotrastaurin concentration node metastasis in colon carcinoma. Smad4 expression showed negative correlation with VEGF-C expression. VEGF-C and Smad4 expression may be clinically useful indicators for prognostic evaluation in patients with colon carcinoma. Key Word(s): 1. VEGF-C; 2. colon carcinoma; 4. Smad4; Presenting Author: HANQING LUO Additional Authors: DONG WU, GUIJUN FEI, HUIJUN SHU, JINGNAN LI, JIAMING QIAN Corresponding Author: DONG WU Affiliations: none Objective: Three consecutive fecal
occult blood tests (FOBT) are widely used for noninvasive screening of organic gastrointestinal diseases. However, its diagnostic yield for colorectal polyps and cancer has not been fully studied. We aim to evaluate this screening strategy for colorectal
polyps and for cancer in a tertiary teaching hospital. Methods: We retrospectively reviewed 303 patients in our department who had undergone standard colonoscopy and three FOBT priorly. The sensitivity and specificity of variable positive FOBTs (0,1,2 or 3) for diagnosing colorectal polyps and cancer were calculated. The impact of colorectal polyps’ location, amount, size, and histological characters on FOBT results were analyzed by logistic regression. Results: The mean age of these patients was 59.5 ± 15.0. Among these 303 patients (male 154), colorectal Hydroxychloroquine polyps were recognized in 169 patients by colonoscopy, and 46 patients were diagnosed with cancer. Compared to patients with normal colonoscopy results, the positive times of FOBT were significantly higher in patients with colorectal cancer (2.3 ± 1.0 vs. 1.2 ± 1.1), and also higher in patients with colorectal polyps (1.6 ± 1.2 vs. 0.6 ± 1.0). As to colorectal polyps, the sensitivity and specificity of positive FOBT were 75.1% and 66.4% for one time, 50.9% and 82.8% for two times, 30.8% and 91.0% for three times. Separately, as to colorectal cancer, the sensitivity and specificity were 91.3% and 34.3% for one time, 80.4% and 63.8% for two times, 54.3% and 80.9% for three times. The amount, size, and histology of colorectal polyps weren’t related to positive FOBT. medchemexpress Polyps located in the left half colon were
more likely to yield positive FOBT (P < 0.05). Conclusion: Three consecutive FOBT can be used as a screening tool for colorectal cancer and polyps. Location of polyps may influence FOBT results. Key Word(s): 1. FOBT; 2. colorectal polyps; 3. colorectal cancer; Presenting Author: GUANGMING FENG Additional Authors: NAIZHONG HU Corresponding Author: NAIZHONG HU Affiliations: the Third Affiliated Hospital of Anhui Medical University; the First Affiliated Hospital of Anhui Medical University Objective: To investigate the expression of Cox-2 and p53 in colorectal adenomas(CRA), and preliminary investigate the significance of expression on the recurrence of CRA. Methods: Collected 108 cases of CRA paraffinembedded tissue specimens, the department of pathology in our hospital from June 2005 to December 2009.