(Delta Psi m). In addition, S-aspirin also prevented A beta-induced activation of p38-mitogen activated protein kinase (MAPK). In conclusion, our results suggest that S-aspirin may protect microglial injury via inhibition of inflammation, prevention of mitochondria
function, and stimulation of cell growth via stimulating p38-MAPK pathway. Our study may suggest that S-aspirin may have potential therapeutic value for the treatment of Alzheimer’s https://www.selleckchem.com/products/Romidepsin-FK228.html disease. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Objectives: High ankle-brachial index (ABI) (>1.40) is associated with poor cardiovascular disease (CVD) prognosis. Concomittant peripheral artery disease (PAD) is frequent, although undetectable with the ABI in this situation. We assessed the prognostic value U0126 of a high ABI according to the coexistence of occlusive PAD in diabetics.
Methods: In this retrospective longitudinal study, we reviewed the data of 403 consecutive diabetic patients (hospitalized in tertiary care teaching hospital) who had a Doppler assessment of their lower limbs between 1999 and 2000. They
were classified as “”normal”" when Doppler waveform patterns (DWP) were normal and ABI within the 0.91 to 1.39 range, “”occlusive-PAD (O-PAD)”" when ABI <= 0.90, or in case of abnormal DWP with normal ABI, “”isolated medial calcinosis (IMC)”" if ABI >= 1.40 with normal DWP, and “”mixed disease (MD)”" when ABI >= 1.40 with abnormal DWP. The primary outcome was the occurrence of any of the following events: death, stroke or transient ischemic attack (TIA), and acute coronary syndrome.
Results: The patients (65.6 +/- 13.2 years, 54.6% females) were classified as normal (14.4%), O-PAD (48.4%), IMC (16.4%), and MD (20.8%). During a mean follow-up of 6.5 years, the event-free survival curves of O-PAD and MD groups showed equally poorer
prognosis than the IMC and normal groups. Adjusted for age, sex, diabetes type and duration, traditional for CVD risk factors, chronic kidney disease, CVD history and treatments, the presence of occlusive disease (hazard ratio [HR]: 2.21, 1.16-4.22, P = .016), but not medial calcinosis, was significantly associated with the primary outcome.
Conclusions: In diabetics with ABI >1.40, only those with concommittant occlusive PAD have poorer prognosis. (J Vasc Surg 2011;53:984-91.)”
“Acid-sensing ion channel 1b (ASIC1b) is a proton-gated Na(+) channel mostly expressed in peripheral sensory neurons. To date, the functional significance of ASIC1b in these cells is unclear due to the lack of a specific inhibitor/blocker. A better understanding of the regulation of ASIC1b may provide a clue for future investigation of its functional importance. One important regulator of acid-sensing ion channels (ASICs) is zinc. In this study, we examined the detailed zinc inhibition of ASIC1b currents and specific amino acid(s) involved in the inhibition.