Score validationFollowing development of the Bedside PEWS score,

Score validationFollowing development of the Bedside PEWS score, we evaluated its convergent validity, responsiveness and construct validity.We hypothesised that Bedside PEWS scores were (1) correlated with nurse-rated risk of near or actual cardiopulmonary arrest, (2) higher in the children who were urgently referred for ICU consultation versus http://www.selleckchem.com/products/PD-0332991.html following ICU discharge, (3) higher in children who were admitted urgently to the ICU than in other patients for whom the ICU was urgently consulted, and (4) that Bedside PEWS scores increased over the 24 hours preceding ICU admission.We compared the Bedside PEWS scores in patients with new consultation and following ICU discharge by the outcome of consultation (ICU admission or not).

Finally, for all visit episodes not resulting in ICU admission we compared the Bedside PEWS scores with the time to the planned follow-up visit. We excluded visits where the follow-up plans were not indicated. The frontline staff of the CCRT were not familiar with the Bedside PEWS score, the score was not calculated, and was not used to assist in management, disposition or follow-up decisions.Analyses and data managementData was entered into an Oracle Database (Redwood Shores, CA, USA). The accuracy of data accuracy was verified by independent manual comparison of all entered data with the case report forms and electronic evaluation for internal consistency. When inconsistencies could not be resolved from the case report form, the original medical record was reviewed.Clinical data was grouped into one-hour blocks for 24 hours ending at PICU admission in cases or the end of 12 hours data collection in controls.

The greatest sub-score for each item in each hour was identified and was used to calculate the Bedside PEWS score for each hour. Logistic regression was used to evaluate the performance of individual items and candidate scores. The AUCROC was determined from the c statistic calculated by the logistic procedure.The maximum scores for control versus case patients were compared by t-test and regression analysis. The maximum PEWS score was calculated for the time intervals: in four-hour blocks relative to ICU admission, over the time described by each nursing survey; for the 12-hour period of the case-control study; and at the point of initial contact of the ICU follow up or urgent referral.The case-control status was then used as the dependent variable in logistic regression analyses. The Entinostat primary analysis compared the maximum Bedside PEWS in cases and controls.

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